The screen measures active B12, the part your cells can actually take up. It can show a shortfall that a standard total B12 result misses.
Vitamin B12 Active. Also called holotranscobalamin, this is the B12 bound to the protein that delivers it into cells, so it reflects the supply your body can use.
Most B12 in the blood is bound to a carrier protein that cells cannot take B12 from. A standard total B12 test counts all of it, so a result can look normal while the usable fraction is low. Active B12 measures only the part on its way into cells. That makes it a more direct signal of a real shortfall, and it tends to fall earlier when supply drops.
B12 is needed for healthy nerves, red blood cells and energy. Low levels can cause tiredness, pins and needles, poor concentration and low mood, often slowly enough that people put it down to stress. It is more common with plant-based diets, with age, after stomach surgery, and in people taking metformin or long-term antacids.
A low active B12 suggests your cells may not be getting enough. The next step is often working out why, since diet, absorption and some medicines all play a part. Your consultant will go through it with you and suggest when to speak to your own doctor.
Results in a grey zone are common. They are read alongside your diet, symptoms and blood count, which is part of the same screen, rather than on their own.
High results usually reflect recent supplements. Without supplements, a raised level is less common and is worth discussing.
Reference ranges differ between labs, and a single result is a snapshot. Your consultant reads every value against your history and the rest of the screen, not in isolation.
This test is part of Baseline’s full blood screen: 122 parameters across ten systems from one draw, for AED 850, with results in 48 hours. It is not sold as a single test, because the result means more next to everything else.
Ranges are the lab’s own. Your consultant goes through what they mean with you.
Your results arrive in the Baseline app, every marker against the lab’s own range, checked by your consultant before you see them. The values above are an example.
This page is general information, not a diagnosis. If you feel unwell, or your symptoms are new or getting worse, speak to a doctor.
Reading is not a diagnosis. A consultation goes through your history with you and tells you plainly whether a program fits, including when it does not. AED 350, credited in full against your first order.